Tolnaftate Drug Profile:

Tolnaftate Drug Profile: Exchange Names: Tinactin Equivalent: Tolnaftato, Tolnaftatum Structure: Fig: Structure of Tolnaftate Synthetic Name: 0-2-naphthyl methyl (3-methyl phenyl thiocarbamate) Depiction: Tolnaftate is a manufactured thiocarbamate utilized as an enemy of contagious specialist that might be sold without clinical remedy in many purviews. It might come as a cream, powder, splash, or fluid vaporized, and is utilized to treat contagious conditions, for example, muscle head tingle, competitors foot and ringworm. It is sold under a few brand names in including Tinactin, scent Eaters, Absorbine, Aftate, Ting (85) . Sub-atomic Weight: 307.41 g/mol System of Action: Tolnaftate is a topical fungicide. Despite the fact that its accurate component obscure, it is accepted to forestall Ergosterol biosynthesis by hindering squalene epoxidase (86) . It has likewise been accounted for to twist the hyphae and to stunt mycelia development in powerless life forms (87) . Dissolving Point: 110-111.50C (230-2330F) Pharmacological Action: Tolnaftate, a pharmacologically inactive new fungicide for topical treatment of shallow mycoses, has been accounted for to be exceptionally compelling in skin diseases brought about by basic pathogenic organisms just as being non-disturbing and non-sharpening. It is a fungicidal invitro. During clinical examination, contemplates demonstrated no adjustments in the blood and pee of patients given tolnaftate topically, recommending that the medication isn't poisonous to the kidney or the hematopoietic framework. Mutilates hyphae and restrains mycelia development in powerless growths. The counter dermatophyte operator to tolnaftate was contrasted and the allylamine against contagious mixes naftifine and terbinafine. Tolnaftate was appeared to restrain sterol biosynthesis at the level squalene epoxidation and squalene was appeared to collect in dermatophytes developed in its essence. Biochemical investigations in entire and broken cells bolstered this end and indicated that the compound w as dynamic against squalene epoxidation in broken candida albicans cells, yet was mwch less strong against entire cells. These outcomes proposed there was a hindrance to entrance in these yeasts (88) . Symptoms: Bothering Pruritus Contact dermatitis Beginning: 24-72 Hours Measurement: Topical/cutaneous: Superficial dermatophyte contaminations, pityriasis versicolor. Grown-up: Apply a 1% gel/arrangement/powder/cream offer for 2 a month and a half; rehash if important. Proceed with treatment for about fourteen days after vanishing of all side effects to forestall repeat of disease. Capacity: Topical/Cutaneous: Store at 15-300C TOLNAFTATE DRUG PROFILE: Exchange Names: Tinactin Equivalent: Tolnaftato, Tolnaftatum Structure: Fig: Structure of Tolnaftate Compound Name: 0-2-naphthyl methyl (3-methyl phenyl thiocarbamate) Depiction: Tolnaftate is a manufactured thiocarbamate utilized as an enemy of contagious operator that might be sold without clinical remedy in many purviews. It might come as a cream, powder, shower, or fluid vaporized, and is utilized to treat contagious conditions, for example, muscle head tingle, competitors foot and ringworm. It is sold under a few brand names in including Tinactin, scent Eaters, Absorbine, Aftate, Ting (85) . Atomic Weight: 307.41 g/mol Instrument of Action: Tolnaftate is a topical fungicide. In spite of the fact that its precise instrument obscure, it is accepted to forestall Ergosterol biosynthesis by repressing squalene epoxidase (86) . It has additionally been accounted for to contort the hyphae and to stunt mycelia development in powerless life forms (87) . Softening Point: 110-111.50C (230-2330F) Pharmacological Action: Tolnaftate, a pharmacologically idle new fungicide for topical treatment of shallow mycoses, has been accounted for to be exceptionally compelling in skin diseases brought about by regular pathogenic growths just as being non-disturbing and non-sharpening. It is a fungicidal invitro. During clinical examination, considers demonstrated no adjustments in the blood and pee of patients given tolnaftate topically, proposing that the medication isn't poisonous to the kidney or the hematopoietic framework. Contorts hyphae and hinders mycelia development in defenseless organisms. The counter dermatophyte operator to tolnaftate was contrasted and the allylamine hostile to parasitic mixes naftifine and terbinafine. Tolnaftate was appeared to repress sterol biosynthesis at the level squalene epoxidation and squalene was appeared to gather in dermatophytes developed in its essence. Biochemical examinations in entire and broken cells bolstered this end and indicated that the compound was dynamic against squalene epoxidation in broken candida albicans cells, however was mwch less powerful against entire cells. These outcomes proposed there was a hindrance to infiltration in these yeasts (88) . Reactions: 1.Irritation 2.Pruritus 3.Contact dermatitis Beginning: 24-72 Hours Measurements: Topical/cutaneous: Superficial dermatophyte diseases, pityriasis versicolor. Grown-up: Apply a 1% gel/arrangement/powder/cream offer for 2 a month and a half; rehash if essential. Proceed with treatment for about fourteen days after vanishing of all side effects to forestall repeat of contamination. Capacity: Topical/Cutaneous: Store at 15-300C 3.2.1 LECITHIN Equivalent words Pc; kelecin; LECITHIN; Alcolec-S; granulestin; L-Lecithin; LIPOID(R)E80; Lecithin, NF; Phospholutein; E322; egg lecithin; LSC 5050; LSC 6040; blended soybean phoaphatides; ovolecithin; Phosal 53 MCT; Phospholipon 100 H; Prokote LSC; soybean lecithin; soybean phospholipids; Sternpur; vegetable lecithin (89) . Structure Where red †choline and phosphate gathering; dark glycerol; green unsaturated fat; Blue soaked unsaturated fat. Substance name 1,2-diacyl-sn-glycero-3-phosphatidylcholine Atomic weight 789 g/mol Portrayal Lecithin happens light yellow to dull earthy colored, straightforward or translucent, thick fluid substance, as white to brown powder or granules, or as a light yellow to dim earthy colored protuberance, having a slight, trademark scent and taste. Distinguishing proof: (1) Place 1 g of lecithin into a kjeldahl cup, include 5 gm of powdered potassium sulfate and 0.5 gm of cupric sulfate, and 20 ml of sulfuric corrosive. Tilt the cup at about 45ËÅ ¡C edge, heat delicately until the effervesense , and raise the temperature to bubbling. After the substance become blue, straightforward arrangement, heat for 1-2 hours, cool and include an equivalent volume of water. Take 5 ml of this arrangement, and include 10 ml of ammonium molybdate arrangement (1 â†' 5), and warmth. A yellow hasten is framed. (2) To 0.5 g of lecithin, include 5 ml of weakened hydrochloric acid(1â†'2), heat in a water shower for 2 hours and channel. Utilize this arrangement is considered as a test arrangement. Perform paper chromatography with 10  µl of the test arrangement, utilizing choline chloride arrangement (1 â†'200) as the control arrangement and a blend of n-butanol, water, and acidic corrosive (4:2:1) as the creating dissolvable. A red o range spot is gotten from the control arrangement is watched. In paper chromatography for the channel paper, utilize a No. 2 channel paper. Stop the improvement when the creating dissolvable ascents around 25 cm, air-dry, splash with Dragendorffs reagent to build up a shading, and see in light (90) . Dissolvability Insoluble in cool water and furthermore CH3)2CO. Dissolvable in around 12 pieces of outright liquor. Solvent in chloroform, oil ether, mineral oil and unsaturated fats. Sparingly solvent in benzene. Insoluble in cool vegetable oils and creature oils (91) . Thickness Thickness of lecithin is straightforwardly impacted by heat. Lower temperature rises to higher thickness and tight clamp versa. The impact of temperature on lecithin thickness is curvilinear, implying that at low temperatures, a little increment in heat causes an elatively bigger abatement in consistency. For instance, a lecithin with a thickness of 10,000 centipoise at 24 0C, may have a consistency of 5000 centipoise at 350C. An expansion in temperature to 460C may bring down the consistency to 3000 centipoise and further increment to 570C would decrease thickness to 2250 centipoise. Blending oil, for example, soybean oil or fish oil, with the lecithin at a pace of 20 % oil and 80 % lecithin as a comparative impact on thickness as raising temperature by 110C. At the end of the day, a standard liquid lecithin with 10,000 centipoise consistency when blended in with 20 % soybean oil would have an inexact thickness of 5000 centipoise (92) Ordinary PROPERTIES Causticity/alkalinity pH = 5.5â€8.0 for a 1 % w/w fluid arrangement Debris 1.5â€3.0 %, contingent on the evaluation and consistency Auto start temperature 360 ºC Thickness (mass) 0.341 g/cm3 Thickness (tapped) 0.557 g/cm3 Thickness (valid) 1.326 g/cm3 Explicit gravity 1.26 Dissolving point Browns at 190â€200  ºC. Scorches at 225â€230  ºC. Glass change temperature is 170â€180  ºC. Iodine number 95-100 for fluid lecithin. 82-88 for powdered lecithin. Saponification number 196 Practical Category Lecithin is a conventional term to assign any gathering of yellow-earthy greasy substances happening in creature and plant tissues, and in egg yolk. It is normally made out of phosphoric corrosive, choline, unsaturated fats, glycerol, glycolipids, triglycerides, and phospholipids. It is regularly utilized as an emulsifying agent.Available in assortment of structures including granules, delicate gels and chewable tablets. Applications: Lecithins are utilized in a wide assortment of pharmaceutical applications. They are additionally utilized in beautifying agents and food items. Lecithins are essentially utilized in pharmaceutical items as scattering, emulsifying, and balancing out operators, and are remembered for intramuscular and intravenous infusions, parenteral nourishment details, and topical items, for example, creams and salves. Lecithins are additionally utilized in suppository bases to decrease the fragility of suppositories, and have been examined for their retention improving properties in an intranasal insulin definition. Lecithins are likewise regularly utilized as a segment of enteral and parenteral sustenance plans. There is proof that phosphatidylcholine (a

Arieanne Evans-Hill Essays (266 words) - Mali Empire, Songhai Empire

Arieanne Evans-Hill November 27, 2017 History of Art 01 Dr. Jones West African Manuscript Questions Significance of original copies to the network. How does this change with Africa's place in European history? Original copies in Timbuktu give another comprehension of West African history. Moderating the original copies is critical to the way of life in light of the fact that rationing history and emphasizing what occurred in the past is the means by which the way of life makes due on the planet. African history is based on oral convention, antiquarians accept that it's not believable but rather it is a source, in any case. Timbuktu makes an interpretation of into something identifying with books. The compositions likewise rendered as devices to show Islamic practices and information in the network. The data in West Africa's original copies is an extraordinary wellspring of normal information which will consistently be useful for instructing. The presence of a composition is a legay inside itself in light of the fact that much after a whole unique culture is a distant memory, recorded history keeps the memory alive always (whenever saved effectively) and gives a dependable method of finding out about it through words. With Timbuktu having compositions and essentially having a long history and built up culture before European colonialism, it refutes the way that Europeans made Africans better when they caught them and put them into servitude. West African and Chinese compositions can be looked at in two different ways: both are fundamental to their separate societies when instructing individuals about the methods of the predecessors or for China's situation, about Buddhist divine beings and their connections just as finding out about and keeping West African and Chinese social history alive right up 'til today.

PresentingMy Prefrosh!

Presenting…My Prefrosh! Howdy fellow prefrosh, future MIT applicants, and MIT students!! Im Abir, a prefrosh, and I was fortunate enough to have the BEST host ever, our very own blogger Hamsika :) Being the amazing person she is, Hamsika asked me to guest blog about CPW and I am going to try to give a glimpse into my CPW experience boy, was it an experience!! Being the eager beaver I am, I decided to book my flight to CPW EARLY in the morning; 6:25 to be exact. Nonetheless, lady luck was NOT on my side Thursday morning, and I arrived five minutes late for checking in my bag and thus missed my flight :( BUT I took it like a man, pulled out my macbook and played Sims 3 until the next flight at 8:45 a.m. Sims 3 or no Sims 3, sitting around at the airport can be a drag.. and having no one to talk to makes it worse! Thus, when I saw a slightly dazed and confused looking girl around my age walking around my departure gate, I introduced myself! Lo and behold, she was a prefrosh too! Amanda, if youre reading this it was quite nice to meet you!!! Add me on facebook ;) I also met Ameesh, a high school friend, and David, a fellow Dallas admit, at the airport! Minor shout out to both of you :D (kind of wish I could tag people.. argh!) After finally getting on my flight two and a half hours later than expected, I sighed with relief and took a LONG nap on my flight from DFW to Boston Logan. My arrival at Logan was welcomed with a myriad of texts from my LOVELY and LOVED MITES friends who were already at MIT. I had the awesome opportunity to spend 6 weeks at MIT last summer, and returning to campus was like returning home from a long long absence. Basically, I WAS PSYCHED to be back!! Despite the gloomy weather, seeing campus again was amazing! From chilling in Simmons, where I remember pulling all nighters trying to do Biochem Psets, to eating the Grills pizza, notorious for its abundant supply of grease, memories definitely washed over me all around campus. Campus from Nu Delta roof top :) Thursday was what I like to call a CHILL day :) I settled down in Hamsikas dorm (where I met her wonderful roomies Manu and Jeanne!) and headed to Downtown Crossing with Hamsika and my MITES bud Tiffany. Coming from Dallas, a city filled with cars and void of pedestrians, Boston strikes me as a city with a quick pulse. Im used to the relaxed and sometimes languid feel of Texas, and spending time in Boston is an exciting setting change. Wherever I looked there was an immense diversity of people, some of whom were quite for lack of a better term sketch looking :S Taking the underground transit system is always an experience we witnessed a shouting match and an extremely packed subway wagon leaving me feeling quite urban and hip ;) On our way to the subway station we got to see this hack! Only at MIT do people hang lounges upside down.. notice how the light is on!!! I got to meet Tim!!! YAY! Super exciting :) Thursday evening I attended the minority dinner and got to meet a bunch of interesting new people! The food was good, but the company was definitely better. The dance exhibits were really entertaining, and as a minority I felt quite welcomed to MIT! Following the minority dinner I headed over to the CPW Welcome where Hamsika 3 made a little speech! Im going to be honest with you all.. I bragged about her IMMENSELY!! I made sure that everyone in my vicinity knew that she was MY host :) After the CPW Welcome there was an awesome festival in the Johnson Athletics Center; I got to meet some really interesting and creative people. Everyone was extremely friendly and happy to see us prefrosh creating an awesome and fun filled atmosphere. Tiffany I with the MIT Shakespeare Ensemble Group Friday was quite a gloomy day.. the rain wouldnt let up but we still managed to have a lot of fun!! I toured the Brain and Cognative Sciences labs with my friends Robert and Grace and was amazed at all the opportunities and the amount of research that MIT conducts. I will confess, I did get a little emotional from time to time; its an incredible blessing to be surrounded by people who are working to better this world. Everyone I met on campus was extremely passionate about their goals, and were equally as passionate to tell you about them. I couldnt help but think that I was surrounded by the people who would cure diseases, create marvels, and better the world in every way possible. MIT brings together people who care, and to be surrounded by them definitely had an impact on me. For dinner MITs Muslim Student Association took some of us muslim prefrosh out for dinner/breakfast (our eating schedules were thoroughly messed up at this point). We had a great time eating and talking but I never managed to finish my french toast :( YUM YUM! Friday night I headed out with my friends to the South Asian Culture Show which was a blast!! Got to see some awesome traditional dancing :) Its really incredible to see the diversity in student activities available at MIT I attended the Meet the Bloggers event where I got to meet both Matt and Quinton!! Very exciting :) Quinton is officially one of my favorite people in the world.. hes just TOO funny! I distinctly remember him posing GQ looking with one of my rings.. but for the sake of his dignity I wont be posting the hilarious pictures (pssst..! check out my CPW album on facebook) Saturday rolled around and I still hadnt explored Boston!!! Some friends and I decided to head to town for some tie dye and food! We first visited TEP, a frat, and made some tie dye shirts :) verrry fun! Also had some spice cream.. the MOST sketch tasting ice cream ive ever had!! We spent the next day roaming the city and I honestly had no clue where we were going.. but somehow my friends got us home at 2 p.m. issssh safe and sound ;) The cutest hack ever :D So excited I got to see it!!!!! Overall CPW was AMAZING! Hectic, fun, and interesting are words that attempt, yet sadly fail, to truly describe the event. I meet some awe inspiring people, and had a weekend full of fun!! If MIT wasnt a strong contender (for some strange reason..) after CPW it should be :) Lots of Love, Abir :)

Review Of The Little Albert Experiment - 1093 Words

Madison Berry October 30, 2014 Section #2 NetID: meberry John Watson and Classical Conditioning In psychology, respondent behavior is behavior learned through classical conditioning. This type of learning is defined as a way in which one learns to link two or more stimuli while also anticipating events; or other wise, known as a kind of learning that occurs when a conditioned stimulus is paired with an unconditioned stimulus. While classical conditioning was accidently discovered by Ivan Pavlov, John B. Watson was interested in taking Pavlov’s experiences a bit further. Watson’s ultimate goal was to research how classical conditioning could be seen through humans and not just through animals. An in depth look on John Watson’s actual experiment can be better explained and found in the article titled, â€Å"The Little Albert Experiment† on http://psychology.about.com/od/classicpsychologystudies/a/little-albert-experiment.htm. John Watson’s Contribution Classical conditioning is identified as the type of learning where the nature of the research conditions a fear response to the subject being experimented on. An implication of the research for human behavior involving conditioned fear response would describe how a child might be afraid of storms because of the partnership between the storm and the sound of the loud thunder. This being said, John B. Watson wanted to further explain this reasoning of classical conditioning through his own experiment that many people call The â€Å"LittleShow MoreRelatedThe Little Albert Experiment Of Classical Conditioning1245 Words   |  5 PagesThe Little Albert Experiment In 1920, behaviorist John B. Watson and his graduate student Rosalie Rayner wanted to study classical conditioning in people. Classical conditioning is when two stimuli are paired and produce an effect off of the second stimulus, but eventually produce the same effect with the first stimulus individually. 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Conditioned emotional reactions. Journal of Experimental Psychology, 3, 1-14.). Little Albert is an significant case in Classical Conditioning (Waston and Rayner, 1920) in which Waston and Rayner used fear conditioning in a toddler using a white rat paired with the loud sound of a hammer hitting a bar. Eventually, Albert came to associate the loud sound with the white rat and displayed signs of fear when witnessing the rat, providing support for theRead MoreHawthornes Quest for Perfection761 Words   |  4 Pageslook young, beautiful, and perfect. Some women even undergo surgeries to perfect their bodies. True natural beauty comes from within one’s self and not what is on the outside. While critics argue that Hawthorne’s â€Å"The Birth Mark,† â€Å"Dr. Heidegger’s Experiment,† and â€Å"Rappaccinni’s Daughter† stand as an overt commentary on nature vs. science, Hawthorne actually uses these works to explore personal familial connections. 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World War I And The Great War - 1325 Words

Annie Poll Period 3 AP European History Free-Response Essay 31 March, 2016 World War I is often called â€Å"The Great War†. This was because it was the first war to affect such a large geographical area and involve so many countries. These countries’ governments had complicated relationships with each other and even the people who they governed. This war was largely unavoidable because of these complicated relationships and diplomacies. The first example of these relationships were the ones countries at this time had with each other: alliances. An alliance is an agreement between two or more countries in which they promise support to each other, this support often relating to military. There were two major alliances that faced off in World War I: the Central Powers and the Triple Entente. The Central Powers were not always called the Central Powers; when the Prussian general Otto von Bismarck united Germany in 1871, he was fearful of the vulnerability of the new united country, and knew he needed alliances. He knew France was not an opti on because of the resentment harbored by the French government after Germany annexed the French province of Alsace-Lorraine, and Britain was not a viable option because of their policy of â€Å"splendid isolation†. So, Germany looked instead to the east and formed the Three Emperors’ league with Russia and Austria-Hungary. After the Treaty of Berlin in 1878, Russia decided they were dissatisfied with the terms and removed themselves fromShow MoreRelatedThe Great War : World War I894 Words   |  4 Pages The Great War: World War I World War I, otherwise known as the Great War, began as a small battle that eventually developed into a prodigious uproar between several countries. 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Evaluation of Business Code of Ethics Free Essays

In preparation for your research paper, write a research proposal that includes the following: †¢ Identify the topic and state the question you will answer in your research. Criminal justice to work in the area as a Probation Officer working in the Juvenile Hall †¢ Provide the rationale for your research question. Refer to the Research Question Appendix on your Week Two student Web site for examples of identifying topics and generating research questions for that topic. We will write a custom essay sample on Evaluation of Business Code of Ethics or any similar topic only for you Order Now 1. Working with gang crime statistics members? 2.Violent offenders? 3. Sex offenders younger than 15? †¢ Describe your research writing purpose. Will you explore a question of fact, definition, value, cause and effect, or consequence? Refer to Ch. 3, Establishing a Purpose. Are you taking a stand on an issue or arguing a point? Refer to the Evaluating Your Purpose checklist in Ch. 16 of Bookmarks. I am explaining the work of a probation officer and what probation officers have to deal with juveniles. †¢ Describe the type of research you will conduct—primary (based on interviews, etc. ) or secondary (based on sources already written).Describe your research strategy by explaining the process you will follow to collect your information. Refer to Ch. 4, Planning Your Research Strategy. It would be secondary research, going online finding valid sources to get the information Begin building a research log: Identify (cite) details of each source and collect facts, statistics, expert opinions, examples, and definitions that address your research question. Include your research log with your research proposal.†¢ List at least five sources in the research log. Research Log Jacobson, Michael. â€Å"Probation Officers. † Encyclopedia of Law Enforcement. Ed. Larry E. Sullivan, et al. Vol. 1: State and Local. Thousand Oaks, CA: Sage Reference, 2005. 369-371. Gale Virtual Reference Library. Web. 22 Apr. 2010. Document URL com/ps/i.do?id=GALE%7CCX3452600164v=2.1u=apolloit=rp=GVRLsw=w†http://go. galegroup. com/ps/i. do? id=GALE%7CCX3452600164v=2. 1u=apolloit=rp=GVRLsw=w How to cite Evaluation of Business Code of Ethics, Papers

Social Issues Of Yesterday And Today Essays - Kennedy Family

Social Issues Of Yesterday And Today Kevin Sellers April 8, 1998 Social Issues of Yesterday and Today Let every nation know, whether it wishes us well or ill, that we shall pay any price, bear any burden, meet any hardship, support any friend or oppose any foe to assure the survival and the success of liberty, (John Fitzgerald Kennedy). The problems and social issues of our nation years ago have become the problems of today. John Fitzgerald Kennedy became the thirty-fifth president of the United States of America on January 20, 1961. Over thirty-five years later, the problems addressed in his Inaugural Speech are still important social issues of this age. One of the most important social issues expressed in this speech was freedom; the freedom of people from the oppression of Communism. John F. Kennedy made a promise to support any friend or oppose any foe to assure the survival and the success of liberty. He believed that he had been granted the role of defending freedom in its hour of maximum danger. But he knew that he was just the starting point, and it would take many generations to undo the oppression of Communism and the damage that it would cause globally. The predictions that were made in his speech were true; he was the beginning of the ending, and it took over thirty years of cold war to put an end to the greatest Communist nation in the world: the USSR. Although the surmise of the USSR has become history, communism is still alive and well today. The Peoples Republic of China is probably the largest of the few communist nations left in the world. Since the times of J.F.K. the United States has developed political tactics to fight the spread of communism rather that the use of war, such as that of Vietnam. The most common political tactics used are trade embargoes. A trade Embargo will not allow a nation or country to sell or trade certain products, or place a high tax on them so that the general consumer will not want to purchase that particular product. Because of trade embargo's we are able to force other nations into submission without the use of force (war). John F. Kennedy also addressed the problem of poverty, not just with our nation, but as a global problem. This issue has been addressed in the past it is being addressed now and, it will be addressed in the future. The problem of poverty is a serious issue in our present generation. Good jobs are hard to find, which means that most of the jobs available are low paying, and that put a lot of people below the poverty line. Another problem associated with poverty is that some people are just lazy. They don't want to work, and why should they when the government will just pay their way? If a free society cannot help the many who are poor, it cannot save the few who are rich (JFK). John Fitzgerald Kennedy indicated many social issues and problems, which needed to be dealt with not only by the government, but by the people as well. He had a vision for America and the world. John F. Kennedy knew that it would take a nation that was united for the common cause of world well being, so he made this call to action. Ask not what your county can do for you--ask what you can do for your country?Ask not what America will do for you, but what together we can do for the freedom of man. Introduction Strategy: Use a quotation Conclusion Strategy: Make a call to action, Close with a statement or quotation readers will remember Social Issues